Jimmy Kimmel Live will have a very different feel to it this week.

Host Jimmy Kimmel is taking the week off to be with his family after his son’s second heart surgery was postponed.

Photo Credit: ScreenshotThe Kimmel family. (L to R) Molly, Jane, William and Jimmy

In Kimmel’s place, the show will have a different guest host every night, starting with NBA legend Shaquille O’Neal on Monday.

Shaq’s guests on the show will be actresses Mila Kunis and Aisha Tyler, while Ty Dolla $ign and YG will provide the music.

Rock icon Dave Grohl will take over the role on Tuesday night, with Kristen Bell appearing on the show and Alice Cooper performing.

Things will get hot and heavy on Wednesday, as Channing Tatum steps into the host role with Ellen DeGeneres as a guest and P!nk providing the music.

On Thursday, Jennifer Lawrence will step into Kimmel’s shoes with Kim Kardashian scheduled to appear as a guest, as well as a performance from Linkin Bridge.

The guest host and appearances for Friday’s show haven’t been revealed yet.